Police and ambulance crews were called to an address in Dean Street at around 4.10am on Sunday to reports of “multiple patients with stab wounds”.
Scotland Yard confirmed a 47-year-old man was found at the scene with knife injuries.
He was taken to hospital where his injuries were described as not “life-changing” or “life-threatening”.
Another man, aged 32, was also taken to hospital with injuries believed to be less serious.
Paramedics from the London Ambulance Service’s Joint Response Units, which works with the police, also said two people were taken to hospital.
The group tweeted: “2 medics responded to reports of multiple patients with stab wounds in Soho with @MPSWestminster, 1 to a major trauma centre & 1 to A&E.”
Police said a section of Dean Street was cordoned off for several hours on Sunday before the road fully reopened at around 1pm.
A Met spokesman said one man was arrested on suspicion of GBH.
