Schools Secretary Ed Balls is due to join forces with Britain's agony aunts for a "relationships summit".
The meeting will see the agony aunts, including Sun columnist Deidre Sanders, advise ministers on what they can do to support children and families affected by relationship problems.
Official figures show that three million of the UK's 12 million children will see their parents separate during the course of their childhood.
About 200,000 to 250,000 couples separate each year, affecting about 350,000 youngsters.
Relationship breakdowns account for almost half of children's emotional and behavioural problems, while children from broken homes are less likely to pass their exams and more likely to leave home and become a parent at an earlier age.
The event follows a meeting between Mr Balls and 17 agony aunts (collectively known as an "anguish") in October, as part of the Kids In The Middle campaign which supports children caught up their parents' relationship difficulties.
Mr Balls is now launching a new Kids In The Middle booklet, written by agony aunts, and will announce a three-point plan aimed at supporting new and first-time parents as well as children caught up in relationship problems.
He will say: "We know Government doesn't bring up children - parents do. And we know in the vast majority of cases in which parents are splitting up they will always try to make sure they put the needs of children first - but sometimes it just isn't possible.
"The risk is that the impact of their parents' break-up can sometimes scar children for life - that is why there is a role for Government to intervene."
He will say: "When I met with agony aunts last month I thought they know better than anyone the heartache that parental separation can cause children and adults. I hope this will be a chance for us all to discuss ways in which we can support separated families better."
