David Cameron has vowed to unleash a "new economic dynamism" as he appealed to business leaders to create the jobs Britain needs to recover from the recession.
Seeking to shift the spotlight from spending cuts and public sector job losses, the Prime Minister promised a "forensic, relentless focus on growth" over the months ahead.
Ministers would be promoting British business and helping create the conditions in which entrepreneurialism could flourish, he told the CBI.
A detailed national infrastructure plan is being published, designed to lever in £200 billion of long-term investment from the public and private sectors.
The Government would also invest more than £200 million over the next four years in technology and innovation centres bringing universities and business together, Mr Cameron announced. "When we say we're going to build a new economic dynamism, we mean it," he said.
He insisted that innovation and job creation in the private sector was essential to help rebuild the economy.
The speech, his first to the CBI as Prime Minister, comes amid concern about the expected 490,000 public sector job losses to be triggered by spending cuts over the next four years.
"In the weeks and months ahead, ministers will be developing detailed plans to turn this strategy into action," he said.
"Everything - from bank lending to skills, green-tech to high-tech, competition to innovation, international trade to local growth - will be put under the microscope. That forensic, relentless focus on growth is what you will get from this government.
"What I need in return from you is a commitment to create and innovate, to invest and grow, to develop and break boundaries. The new jobs, the new products, the new ideas that will lift us up will be born in the factories and offices you own - not in the corridors of Whitehall."
