Chelsea have lost for the first time under Maurizio Sarri after a 3-1 defeat in the London derby against Tottenham at Wembley.
Goals from Dele Alli, Harry Kane and Heung-min Son, before a consolation from Olivier Giroud, sealed an emphatic win for Spurs as they climbed to third in the table.
The defeat means that Chelsea lose their status as the only team left in Europe's top five leagues to have not lost a game, having gone 16 games without defeat in all competitions under Sarri before the loss on Saturday.
Sarri's side had won all four of their Europa League group games and eight games in the Premier League, with four draws, and even saw the Italian break the Premier League record for most games unbeaten from a new manager.
Liverpool and Manchester City remain unbeaten in the Premier League after their respective 3-0 and 4-0 victories over Watford and West Ham on Saturday.
However, both side lost in the Champions League group stages.
Paris Saint-Germain, meanwhile, have set a new domestic record in Ligue 1 by winning all 14 games in the league this season. However, the French champions lost 3-2 at Anfield in September.
Juventus have also stayed unbeaten in the Serie A, winning 12 of their 13 games this season, but relinquished their unbeaten record in all competitions when they were stunned 2-1 at home by Manchester United.
