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Louis van Gaal has loaded up his strike force as Manchester United look to improve their poor form that has seen them slip to fourth in the Premier League.
Manchester United will be without Michael Carrick for around four weeks as he has a ruptured muscle in his calf.
Van Gaal looks to have reverted to his wing-back system as he makes three changes to the team that were held to a 0-0 draw at Cambridge.
Rooney returns to the starting line-up alongside Robin van Persie, so the hosts wont be without expensive firepower as they look to improve their scoring output.
United won't be taking Leicester for granted after their shock 3-5 defeat Nigel Pearson's men earlier in the season, and the visitors make two changes from the side that beat Tottenham in the FA Cup fourth round last weekend.
Things are still tight at the foot of the table, and Leicester could advance to safety with a win if other results go their way.
TEAMS IN FULL
Manchester United starting XI: De Gea, Valencia, Jones, Rojo, Shaw, Blind, Januzaj, Di Maria, Rooney, van Persie, Falcao
Substitutes: Valdes, McNair, Smalling, Fellaini, Herrera, Mata, Wilson
Leicester City starting XI: Schwarzer, Simpson, Morgan, Wasilewski,, De Laet,, King, Drinkwater Schlupp Kramaric Ulloa.Vardy
Substitutes: Hamer, Konchesky, Upson, Hammond, Albrighton, Cambiasso, Nugent.
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