Robin van Persie started on the bench as Manchester United chased the point required to seal a top seeding for the knock-out stage of the Champions League against Shakhtar Donetsk at Old Trafford.
Van Persie has been troubled by a groin injury and was rested in readiness for Sunday's important Premier League trip to Aston Villa.
Manager David Moyes made six changes to the side beaten by Newcastle on Saturday, including the return of Wayne Rooney, a first European outing of the season for Alexander Buttner and Ashley Young's return to the starting line-up after an eight-game absence.
Man Utd: De Gea, Rafael Da Silva, Ferdinand, Evans, Buttner, Jones, Giggs, Young, Kagawa, Januzaj, Rooney. Subs: Lindegaard, Anderson, Hernandez, Nani, van Persie, Cleverley, Valencia.
Shakhtar Donetsk: Pyatov, Srna, Kucher, Rakitskiy, Shevchuk, Fred, Stepanenko, Douglas Costa, Alex Teixeira, Taison, Luiz Adriano. Subs: Kanibolotskiy, Hubschman, Bernard, Eduardo, Fernando, Ferreyra, Kryvtsov.
