West Ham owners David Sullivan and David Gold have urged the club's fans not to invade the pitch at the end of next week's final game at the Boleyn Ground.
The Hammers are set to end their 112-year stay at Upton Park, prior to their move to the Olympic Stadium this summer, when they host Manchester United on Tuesday night.
West Ham plan to mark the occasion with a special celebratory event, the majority of which will be kept under wraps until the night itself.
Every player to have made a first-team appearance for the club has been invited to attend the game as a guest but supporters have been warned the celebrations could be cut short if they enter the field of play.
West Ham's final season at the Boleyn Ground
Sullivan and Gold told the club's official website in a joint statement: "To make it special we need your support.
"Any incursions on to the pitch will certainly mean cancelling the current squad’s richly-deserved lap of appreciation and denying some of our greatest ever players the chance to take the field for the final time.
"That would be a tragedy; for them and the Boleyn Ground.
"It will certainly be an incredibly emotional day from start to finish but I think if we were to have wished for a fitting fixture to bid goodbye to 112 years of history at the Boleyn, Manchester United under the lights would have been near the top of our list," they added.
West Ham still harbour hopes of a top-four finish and Slaven Bilic's side will climb above the Red Devils into fifth place with victory.
